Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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5,161 – 5,175 of 60,541 results

5,161

Cayman Chemical FRAX597, Purity: ≥98%, CAS: 1286739-19-2, 25 mg

A PAK inhibitor selective for group I PAKs (IC50s = 7.7, 12.8, and 19.3 nM for PAK 1, 2, and 3, respectively) over group II PAKs (IC50 > 10 µM for PAK4 and 50 = 70 nM); reduces proliferation and survival of transformed Schwann cells, ovarian, and pancreatic cells; works synergistically with gemcitabine in pancreatic cancer models in vitro and in vivo

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5,162

Cayman Chemical SW155246, Purity: ≥98%, CAS: 420092-79-1, 10 mg

A DNMT1 inhibitor (IC50 = 1.2 μM); selective for human DNMT1 over murine DNMT3 (IC50 = 38 μM); inhibits HeLa and A549 tumor cell growth in a redox-independent manner (IC50s = 8-20 μM); inhibits genomic methylation in HeLa cells from 10 to 18.6 μM

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5,163

Medchemexpress LLC DREADD agonist 21 dihydrochloride | 2250025-92-2 | 98.9% | 351.27 g/mol | C17H20Cl2N4 | 1 ML

DREADD agonist 21 dihydrochloride is a water-soluble dihydrochloride salt of a potent chemogenetic ligand that selectively activates designer muscarinic receptor hM3Dq (EC50 = 1.7 nM). It is supplied for research use and is used to remotely control neuronal activity in vitro and in vivo studies.

Potent, selective hM3Dq agonist (EC50 = 1.7 nM).
Water-soluble dihydrochloride salt for improved handling and formulation.
Available as a solid and as a 10 mM solution in DMSO for flexible use.
High purity (~98.9%) suitable for research applications.
High solubility in DMSO and water to facilitate stock preparation.

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5,164

Selleck Chemical LLC 5-Ph-IAA E8177-5MG

The 5-Ph-IAA is a bumped-IAA analogue that establishes the auxin-inducible degron 2 (AID2) system with the OsTIR1(F74G) mutant enabling precise rapid degradation with 670-fold lower ligand concentration It induces rapid and efficient depletion of mAID-fused proteins to study protein function in living cells exhibiting significant tumor suppression properties

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5,165

Medchemexpress LLC FGFR-3 alpha IIIc 50ug | 50ug

The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes particularly in chondrocytes osteoblasts and inner ear development Its effects span normal skeletal development and postnatal bone mineralization FGFR-3 alpha (IIIc) Protein Human (Biotinylated HEK293 His-Avi) is the recombinant human-derived FGFR-3 alpha IIIc protein expressed by HEK293 with C-Avi C-His labeled tag

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5,166

Cayman Chemical Gap 27 (trifluoroacetate salt), Purity: ≥98%, 5 mg

A connexin-mimetic peptide; reduces survival of isolated rat osteoclasts at 500 µM; decreases bone resorption in rat bone slice and osteoclast co-cultures; accelerates wound closure and stratification of the corneal epithelium in isolated human corneas; reduces cardiac remodeling and the incidence of cardiac arrhythmias in a rat model of AV-shunt surgery-induced high-output heart failure

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5,167

Cayman Chemical XL388, Purity: ≥98%, CAS: 1251156-08-7, 50 mg

An orally bioavailable and ATP-competitive inhibitor of mTOR (IC50 = 9.9 nM); selective for mTOR over a panel of more than 140 kinases, including various PI3Ks (IC50s = >3,000 nM); inhibits mTORC1 and mTORC2 in vitro (IC50s = 8 and 166 nM, respectively); induces cytotoxicity in MG-63, U2OS, and Saos-2 osteosarcoma and 786-0 kidney cancer cells and increases apoptosis in 786-0 and MG-63 cells; induces cell cycle arrest at the G1 phase and increases autophagy in MG-63 cells; reduces tumor growth in an MCF-7 breast cancer mouse xenograft model at 50 and 100 mg/kg; inhibits phosphorylation of mTORC1 and mTORC2 substrates p70S6K, S6, 4E-BP1, and Akt in MCF-7 and PC-3 xenograft tumors at 100 mg/kg; reduces tumor growth in U2OS and 786-0 mouse xenograft models at 20 mg/kg

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5,168

Cayman Chemical Salbutamol, Purity: ≥98%, CAS: 18559-94-9, 50 mg

A β2-AR agonist; induces bronchodilation in isolated guinea pig trachea rings (EC50 = 19 nM); selectively binds to the β2-AR over the β1-AR and β3-AR in CHO cells expressing the human receptors (Kds = 0.76, 21, and 46 μM, respectively); reduces acetylcholine-induced bronchospasm in anesthetized guinea pigs at 25 and 50 μg/kg, i.v.; reduces the response of bronchial muscle to efferent vagal stimulation in anesthetized cats and dogs; reduces transpulmonary pressure in recurrent airway obstruction-affected horses (ED50 = 43.6 μg/animal) when administered via nebulization

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5,169

Cayman Chemical Davercin, Purity: ≥98%, CAS: 55224-05-0, 10 mg

A macrolide antibiotic; inhibits bacterial protein synthesis by targeting the 50S ribosomal subunit; has broad-spectrum activity against various Gram-positive and Gram-negative bacteria (MICs = 0.02-50 μg/ml); non-toxic to mice and rats (LD50s = 4.05 and 5.9 g/kg, respectively)

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5,170

Cayman Chemical X-376, Purity: ≥98%, CAS: 1365267-27-1, 25 mg

An ALK and MET inhibitor (IC50s = 0.61 and 0.69 nM, respectively); selectively inhibits the growth of cancer cell lines harboring gain-of-function ALK-fusion proteins (IC50s = 32-150 nM) over those with cell growth driven by other mutant kinases (IC50s = 1,427->3,000 nM); reduces tumor growth in an NCI H3122 lung cancer mouse xenograft model at 50 mg/kg

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5,171

Cayman Chemical JNJ-38877605, Purity: ≥98%, CAS: 943540-75-8, 5 mg

An ATP-competitive inhibitor of Met kinase (IC50 = 4 nM); at least 600-fold selective for Met in a panel of ~250 tyrosine and serine-threonine kinases; inhibits the growth of cancer cell lines with MET gene amplification (IC50s = 11-50 nM) but has no effect on the growth of control cells with normal MET gene copy number or no MET expression; sensitizes tumors to radiotherapy in U251 glioma and MDA-MB-231 breast cancer mouse xenograft models and increases apoptosis in irradiated tumors in the MDA-MB-231 mouse xenograft model at 50 mg/kgp; reduces tumor size by 6-fold and the number of blood vessels in tumors by 80% in an RU-P melanoma mouse xenograft model at 20 mg/kg

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5,172

Medchemexpress LLC CD94 Human HEK293 50ug

CD94 protein is a key immune receptor for self-non-self discrimination It forms a complex with KLRC1 or KLRC2 on lymphocyte subsets and recognizes HLA-E loaded with self-peptides It allows cytotoxic cells to monitor MHC class I expression and promote self-tolerance CD94 Protein Human (HEK293 His) is the recombinant human-derived CD94 protein expressed by HEK293 with N-6 His labeled tag

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5,173

Medchemexpress LLC Propanidid 10mg | 1421-14-3 | 337.41 g/mol | C18H27NO5 | 10 MG

Propanidid is a short-acting, non-barbiturate general anesthetic and γ-aminobutyric acid type A (GABAA) receptor agonist supplied for research use. This 10 mg package is intended for laboratory studies; the compound has molecular formula C18H27NO5, molecular weight 337.41 g/mol, and reported purity of 98.19%.

Short-acting GABAA receptor agonist suitable for anesthetic pharmacology research
Provided as a 10 mg research-grade solid for small-scale experiments
High listed purity (98.19%) supports reproducible results
Known molecular formula C18H27NO5 and molecular weight 337.41 g/mol
Requires appropriate handling and storage per safety protocols

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5,174

Medchemexpress LLC Ethoxybenzene | 103-73-1 | 500g

Ethoxybenzen can be used as an analyte to determine the properties of porous graphitic carbon (PGC) particles[1]

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5,175

Selleck Chemical LLC GNE-987-E1664-1MG

GNE-987 is a BRD4-degradating PROTAC consisting of BRD4B1 and BRD4B2 (BRD4 bromodomains 1 and 2) and the VHL E3-ubiquitin ligase It exhibits BRD4 degradation activity with DC50 of 0 03 nM for the EOL-1 AML cell line GNE-987 inhibits cell proliferation and induces apoptosis by promoting the rapid and sustained degradation of BRD4 and inhibiting its downstream targets It also demonstrates potent antitumor activity in AML cell lines

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Medchemexpress LLC DREADD agonist 21 dihydrochloride | 2250025-92-2 | 98.9% | 351.27 g/mol | C17H20Cl2N4 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC FGFR-3 alpha IIIc 50ug | 50ug Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC CD94 Human HEK293 50ug Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Propanidid 10mg | 1421-14-3 | 337.41 g/mol | C18H27NO5 | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Ethoxybenzene | 103-73-1 | 500g Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC DREADD agonist 21 dihydrochloride | 2250025-92-2 | 98.9% | 351.27 g/mol | C17H20Cl2N4 | 1 ML

Medchemexpress LLC FGFR-3 alpha IIIc 50ug | 50ug

Medchemexpress LLC CD94 Human HEK293 50ug

Medchemexpress LLC Propanidid 10mg | 1421-14-3 | 337.41 g/mol | C18H27NO5 | 10 MG

Medchemexpress LLC Ethoxybenzene | 103-73-1 | 500g